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During endometrial preparation, is it better to do the natural cycle or the substituted cycle?

By Mark P. Trolice MD, FACOG, FACS, FACE (gynecologist on Fertility CARE: The IVF Center).
Last Update: 09/03/2018

In cycles with frozen embryos, pregnancy rates per embryo transfer are the same whether the cycle is natural or substituted (with medication). No medication is needed for a natural cycle, which reduces the cost of treatment. However, setting a precise transfer date is more complicated than a substituted cycle.

 Mark P. Trolice
Mark P. Trolice
MD, FACOG, FACS, FACE
Gynecologist on Fertility CARE: The IVF Center
Mark P. Trolice, M.D., FACOG, FACS, FACE is Director of Fertility CARE – The IVF Center and Clinical Associate Professor in the Department of Obstetrics & Gynecology (OB/GYN) at the University of Central Florida College of Medicine. He is Board-certified in REI and OB/GYN, and maintains annual recertification. His colleagues select him as Top Doctor in America® annually, one among the top 5% of doctors in the U.S.
Florida license: ME 78893
Gynecologist. Mark P. Trolice, M.D., FACOG, FACS, FACE is Director of Fertility CARE – The IVF Center and Clinical Associate Professor in the Department of Obstetrics & Gynecology (OB/GYN) at the University of Central Florida College of Medicine. He is Board-certified in REI and OB/GYN, and maintains annual recertification. His colleagues select him as Top Doctor in America® annually, one among the top 5% of doctors in the U.S. Florida license: ME 78893.