Although performing PGD of embryos generated through IVF-ICSI has many advantages, as well as a higher success rate of the treatment, it also has some disadvantages.
The process of PGD requires the manipulation of the embryos and, sometimes, the embryos do not survive. Furthermore, this can lead to the cancellation of the cycle because there are no genetically normal embryos. To these disadvantages must be added the ethical problems that the performing of PGD may entail since there are people who think that life begins from the moment fertilization occurs.
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